ومن كلام له (عليه السلام) وقد وقعت مشاجرة بينه وبين عثمان، فقال المغيرة بن الاخنس لعثمان: أنا أكِفيكَه، فقال أميرالمؤمنين صلوات الله عليه للمغيرة:
There was some exchange of words between ‘Uthmān ibn ‘Affān and Amīr al-mu’minīn when al-Mughīrah ibn al-Akhnas  said to ‘Uthmān that he would deal with Amīr al-mu’minīn on his behalf whereupon Amīr al-mu’minīn said to al-Mughīrah:
O son of the accursed and issueless, and of a tree which has neither root nor branch. Will you deal with me? By Allāh, Allāh will not grant victory to him whom you support, nor will he be able to stand up whom you raise. Get away from us. Allāh may keep you away from your purpose. Then do whatever you like. Allāh may not have mercy on you if you have pity on me.
 al-Mughīrah ibn al-Akhnas ath-Thaqafī was among the well-wishers of ‘Uthmān ibn ‘Affān and the son of his paternal aunt. His brother Abu’l-Ḥakam ibn al-Akhnas was killed at the hands of Amīr al-mu’minīn in the battle of Uḥud, because of which he bore malice against Amīr al-mu’minīn. His father was one of those people who accepted Islam at the time of fall of Mecca but retained heresy and hypocricy in heart. That is why Amīr al-mu’minīn called him accursed, and he called him issueless because he who has a son like al-Mughīra deserves to be called issueless.